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ISSN 1673-9159

主管 广东省高等教育厅

主办 广东海洋大学

富DHA-磷脂酰胆碱对双酚S致小鼠肝损伤的影响

2023. 富DHA-磷脂酰胆碱对双酚S致小鼠肝损伤的影响. 广东海洋大学学报, 43(6): 138-145. doi: 10.3969/j.issn.1673-9159.2023.06.016
引用本文: 2023. 富DHA-磷脂酰胆碱对双酚S致小鼠肝损伤的影响. 广东海洋大学学报, 43(6): 138-145. doi: 10.3969/j.issn.1673-9159.2023.06.016
DONG Jiayu, TIAN Shanshan, QIAN Li, JIANG Su, TANG Yunping. 2023. Effects of DHA-enriched Phosphatidylcholine on Bisphenol S-induced Liver Injury in Mice. Journal of Guandong Ocean University, 43(6): 138-145. doi: 10.3969/j.issn.1673-9159.2023.06.016
Citation: DONG Jiayu, TIAN Shanshan, QIAN Li, JIANG Su, TANG Yunping. 2023. Effects of DHA-enriched Phosphatidylcholine on Bisphenol S-induced Liver Injury in Mice. Journal of Guandong Ocean University, 43(6): 138-145. doi: 10.3969/j.issn.1673-9159.2023.06.016

富DHA-磷脂酰胆碱对双酚S致小鼠肝损伤的影响

  • 基金项目:

    浙江省基础公益研究计划项目(LTGD23D060001)

详细信息
    作者简介:

    董佳昱(1999-),女,硕士研究生,研究方向为海洋药物与生物制品。E-mail:djy1152512751163@163.com

  • 中图分类号: TS254.1

Effects of DHA-enriched Phosphatidylcholine on Bisphenol S-induced Liver Injury in Mice

  • Fund Project: 浙江省基础公益研究计划项目(LTGD23D060001)
  • 【目的】研究从大西洋鲱(Clupea harengus)鱼籽中提取的富二十二碳六烯酸-磷脂酰胆碱(DHA-PC)对双酚S(BPS)诱导的小鼠肝损伤的改善作用。【方法】将24只雄性C57BL/6小鼠随机分成对照组、BPS模型组和DHA-PC给药组,每组8只,模型组和给药组分别给予5 mg·(kg·d)-1 BPS,给药组同时灌胃80 mg·(kg·d)-1 DHAPC,饲养10周。监测各组小鼠的食物摄入量、体质量、肝功能、附睾脂肪指数、肝脏组织病理学分析、肝脏组织中炎症因子和氧化应激等指标,研究DHA-PC对BPS诱导的小鼠肝损伤的改善作用。【结果】BPS处理后,模型组小鼠体质量、肝脏指数、附睾脂肪指数显著升高(P<0.05),但经DHA-PC饲喂治疗后,均呈现下降趋势。所有组别小鼠的食物摄入量、能量摄入量无差异(P>0.05)。病理学结果显示模型组小鼠肝脏肝索消失,肝脏发生局灶性脂肪性病变,给药组肝索恢复,中央静脉重现。与模型组相比,DHA-PC给药组显著降低谷丙转氨酶(ALT)、谷草转氨酶(AST)、白介素(IL)-1β、IL-6、肿瘤坏死因子(TNF)-α、胆固醇(TC)、甘油三酯(TG)、游离脂肪酸(NEFA)、低密度脂蛋白(LDL-C)和丙二醛(MDA)的含量(P<0.05),显著提高高密度脂蛋白(HDL-C)、总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)和过氧化氢酶(CAT)的含量(P<0.05)。【结论】鲱鱼鱼籽源DHA-PC可通过抑制炎症、改善脂质代谢紊乱和氧化应激等途径有效改善BPS诱导的小鼠肝损伤。
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出版历程
收稿日期:  2023-06-05

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