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ISSN 2095-1388

主管 辽宁省教育厅

主办 大连海洋大学

连翘脂素(PHI)对微囊藻毒素(MCs)所诱发大鳞副泥鳅肝脏损伤的保护作用

2023. 连翘脂素(PHI)对微囊藻毒素(MCs)所诱发大鳞副泥鳅肝脏损伤的保护作用. 大连海洋大学学报, 38(6): 980-986. doi: 10.16535/j.cnki.dlhyxb.2023-078
引用本文: 2023. 连翘脂素(PHI)对微囊藻毒素(MCs)所诱发大鳞副泥鳅肝脏损伤的保护作用. 大连海洋大学学报, 38(6): 980-986. doi: 10.16535/j.cnki.dlhyxb.2023-078
RUAN Weilin, BI Xiangdong, DONG Shaojie, YOU Hongzheng, ZHANG Dajuan, QIN Genghua, ZHANG Chunxin, DAI Wei. 2023. Protective effect of phillygenin (PHI) on liver injury induced by microcystins (MCs) in loach (Paramisgurnus dabryanus). Journal of Dalian Ocean University, 38(6): 980-986. doi: 10.16535/j.cnki.dlhyxb.2023-078
Citation: RUAN Weilin, BI Xiangdong, DONG Shaojie, YOU Hongzheng, ZHANG Dajuan, QIN Genghua, ZHANG Chunxin, DAI Wei. 2023. Protective effect of phillygenin (PHI) on liver injury induced by microcystins (MCs) in loach (Paramisgurnus dabryanus). Journal of Dalian Ocean University, 38(6): 980-986. doi: 10.16535/j.cnki.dlhyxb.2023-078

连翘脂素(PHI)对微囊藻毒素(MCs)所诱发大鳞副泥鳅肝脏损伤的保护作用

  • 基金项目:

    国家自然科学基金面上项目(32172978);天津市科技计划项目(22JCYBJC00430,22ZYCGSN00050);甘肃省科技计划项目(21CX6NP223)

详细信息
    作者简介:

    阮威霖(1996-),男,硕士研究生。E-mail:826535878@qq.com

  • 中图分类号: S 949

Protective effect of phillygenin (PHI) on liver injury induced by microcystins (MCs) in loach (Paramisgurnus dabryanus)

  • Fund Project: 国家自然科学基金面上项目(32172978);天津市科技计划项目(22JCYBJC00430,22ZYCGSN00050);甘肃省科技计划项目(21CX6NP223)
  • 为探究连翘脂素(phillygenin,PHI)对亚慢性毒性浓度微囊藻毒素(microcystins,MCs)诱发的大鳞副泥鳅(Paramisgurnus dabryanus)肝脏损伤的保护作用,对体质量为(100.13 ±5.23 )g的泥鳅腹腔注射剂量为17 μg/kg(体质量,下同)MCs 1 d后,分别连续注射3 d不同剂量的PHI(累计剂量0.3、0.6、1.2、2.4 mg/kg),第6天时取泥鳅肝脏样品,比较肝脏组织病理、谷丙转氨酶(ALT)活性、氧化损伤相关指标[丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、谷胱甘肽还原酶(GR)]及炎性因子[白细胞介素1β(IL-1β)和肿瘤坏死因子α(TNF-α)]水平变化。结果表明:MCs可诱导泥鳅肝脏组织发生病理损伤;与对照组相比,MCs组泥鳅ALT活性、MDA含量及IL-1β和TNF-α两种炎性因子水平均显著升高(P<0.05),3种抗氧化酶活性显著降低(P<0.05);与MCs组相比,注射PHI能减轻MCs诱发的泥鳅肝脏组织病理损伤,显著降低肝脏中ALT活性、MDA含量及IL-1β和TNF-α两种炎性因子水平(P<0.05),显著提高肝脏中SOD、GSH-PX和GR活性(除0.3 mg/kg PHI剂量组外)(P<0.05)。研究表明,PHI能够减轻MCs引起的泥鳅肝脏组织病理与生理功能损伤、氧化损伤和炎症反应,对MCs所致肝脏损伤具有保护作用。
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出版历程
收稿日期:  2023-04-11

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