首页 >  大连海洋大学学报 >  皮质醇对鱼类性别分化过程的影响及调控机制研究进展

2023, 38(4): 726-736. doi: 10.16535/j.cnki.dlhyxb.2022-293

皮质醇对鱼类性别分化过程的影响及调控机制研究进展

1. 大连海洋大学 海洋科技与环境学院, 辽宁 大连 116023;

2. 设施渔业教育部重点实验室(大连海洋大学), 辽宁 大连 116023;

3. 辽宁省河鲀良种繁育及健康养殖重点实验室, 辽宁 大连 116023;

4. 浙江大学 生物系统工程与食品科学学院, 浙江 杭州 310058

收稿日期:2022-09-28

基金项目:   国家自然科学基金青年基金(31902347);国家海水鱼产业技术体系资助(CARS-47);辽宁省科技厅面上项目(2022-MS-351);辽宁省教育厅科研项目(LJKMZ20221092,LJKZ0712);大连市重点领域创新团队项目(2021RT07);辽宁省科技特派团项目(2022JH5/10400070) 

关键词: 皮质醇 , 鱼类性别分化 , 环境因子 , 分子机制

Advances in effects and regulatory mechanism of cortisol on process of sex differentiation in fish: a review

1. College of Marine Science and Environment, Dalian Ocean University, Dalian 116023, China;

2. Key Laboratory of Environment Controlled Aquaculture (Dalian Ocean University), Dalian 116023, China;

3. The Key Laboratory of Pufferfish Breeding and Culture in Liaoning Province, Dalian 116023, China;

4. College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China

Received Date:2022-09-28

Keywords: cortisol , sex differentiation of fish , environmental factor , molecular mechanism

鱼类的性别决定与分化一直是发育生物学、繁殖生理学及鱼类遗传育种学领域的研究热点,与高等脊椎动物不同,鱼类的性别决定与分化具有较强的可塑性,容易受到许多环境因素如温度、种群密度和pH等的影响。探究鱼类的性别决定与分化的分子机制对鱼类性别控制育种至关重要,也有利于提高鱼类养殖效益。皮质醇(cortisol)作为鱼类最主要的糖皮质激素,在鱼类性别分化过程中具有重要作用,本文综述了鱼类性别分化与性转变过程中,外源皮质醇影响鱼类的性别分化、环境因素影响内源皮质醇水平的变动规律,以及皮质醇调控性别分化与性转变的分子机制,并提出未来应在皮质醇诱导鱼类雄性化的作用机制、皮质醇与表观遗传因子的互作关系等方面重点开展研究,以期为深入探究皮质醇的功能特性及调控机理提供科学参考。

Sex determination and differentiation of fish has been increasingly concerned in the fields of developmental biology, reproductive physiology, and genetics and breeding in recent years. Unlike other vertebrates, sex determination and differentiation of fish are featured by high plasticity, and is influenced by several environmental factors such as temperature, density, and pH. Exploration of the molecular mechanism of sex determination and differentiation of fish is crucially important for sex control breeding, and conducive to improving aquaculture efficiency. Recently, is proved cortisol, the predominant glucocorticoid in fish, has an important role in the process of sex differentiation in fish. The effects of exogenous cortisol treatment on fish sex differentiation, the effects of environmental factors on the variation pattern of endogenous cortisol levels during fish sex differentiation and sex change, and the molecular mechanism of cortisol in regulating sex differentiation and sex change are summarized. Some suggestions for future research are proposed including understanding of the mechanism of cortisol-induced masculinization and the interaction of cortisol and epigenetic factors, aiming to provide theoretical reference for further exploring the functional and regulatory roles of cortisol.

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皮质醇对鱼类性别分化过程的影响及调控机制研究进展