首页 >  水生态学杂志 >  水环境中镉对鱼类的毒理效应研究进展

2022, 43(2): 142-150. doi: 10.15928/j.1674-3075.202009270279

水环境中镉对鱼类的毒理效应研究进展

1. 长江科学院流域水环境研究所, 湖北 武汉 430010;

2. 流域水资源与生态环境科学湖北省重点实验室, 湖北 武汉 430010

通讯作者: 王振华, 正高级工程师。347785272@qq.com

收稿日期:2020-09-27

基金项目:   国家自然科学基金区域创新发展联合基金重点项目(U21A20156)  长江科学院技术开发和成果转化推广项目(CK-ZS2017008/SH)。 

关键词: 水环境 , , 鱼类 , 毒理效应

Research Progress on the Toxicity of Cadmium to Fish

1. Basin Water Environmental Research Department, Yangtze River Scientific Research Institute, Wuhan 430010, P. R. China;

2. Key Lab of Basin Water Resource and Eco-environmental Science in Hubei Province, Wuhan 430010, P. R. China

Corresponding author: , 正高级工程师。347785272@qq.com

Received Date:2020-09-27

Keywords: aquatic environment , cadmium , fish , toxicological effect

镉在鱼类体内具有生物富集与毒理效应,本文从组织结构与功能完整性、生理代谢、生殖和免疫系统等方面总结了国内外研究进展,为更好地控制水环境中镉污染,保护水环境和水生生物提供科学依据。鱼类食性和摄食途径的差异造成镉在其体内的积累和分布具有生物特异性与组织差异性;水体镉浓度超标可导致鱼类的鳃和肝脏等组织结构与功能完整性受到不同程度损害,并对鱼类的抗氧化防御系统、生殖调控、非特异性免疫系统与基因表达等产生毒性效应,其毒性效应随镉暴露浓度、暴露时间、鱼类种类、发育阶段和性别不同而异;鱼类的抗氧化防御系统和免疫系统在镉诱导的氧化损伤中发挥了重要的保护作用。展望今后的研究方向,应加强低剂量和长周期镉胁迫的影响、水中镉与其他环境污染物的复合毒理效应、不同形态镉的毒理效应及机制等方面研究。

Cadmium is widely distributed in the aquatic environment and accumulates in aquatic organ⁃ isms, effecting their metabolism and threatening human health through the food chain. In this paper, we se⁃ lected fish as a representative aquatic organism and reviewed the toxicological effects of cadmium on fish, considering physiology, metabolism, reproduction and the immune system. The accumulation and distribu⁃ tion of cadmium in fish are biologically specific and histologically different because of the diversity of feeding habits and metabolic pathways. Excess cadmium concentration results in various degrees of dam⁃ age to the structure and functional integrity of gills and liver as well as effects on reproduction, the anti-ox⁃ idant system, innate immune system and gene expression. Toxic effects vary with cadmium exposure lev⁃ el, exposure time, fish species, developmental stage and sex. At the same time, the antioxidant system and immune system of fish play an important protective role in cadmium induced tissue damage. To better con⁃ trol cadmium pollution in the aquatic environment, protect aquatic ecology and aquatic organisms, and to provide safe aquatic products for human beings, we recommend further research on the chronic toxic ef⁃ fects of cadmium on fish at low exposure levels, the combined toxic effects of cadmium and other water pollutants and the toxic effects and mechanisms of cadmium in different forms.

参考文献

[1] 安晶晶,谢冬梅,李英文,等,2019.低剂量镉暴露对雄性斑马鱼生殖内分泌的干扰[J].动物科学,36(2):25-30.
[2] 柏世军,许梓荣,2006.镉对黄颡鱼鳃线粒体结构和能量代谢的影响[J].应用生态学报,17(7):1213-1217.
[3] 蔡荣,郭赛男,郑家浪,2018.Cd2+暴露对斑马鱼肝脏和卵巢抗氧化和免疫系统的影响及蓝LED光预暴露的保护作用[J].生态毒理学报,13(1):169-178.
[4] 曾晨,郭少娟,杨立新,2018.汞、镉、铅、砷单一和混合暴露的毒性效应及机理研究进展[J].环境工程技术学报,8(2):221-230.
[5] 曾善美,2020.镉离子胁迫对中华乌塘醴(Bostrychus sinensis)生物学特性影响及部分抗氧化基因差异表达分析[D].舟山:浙江海洋大学.
[6] 陈春亮,张际标,卢仕严,等,2012.湛江港鱼类不同器官富集铜、镉的特征及评价[J].环境科学与技术,35(61):365-369.
[7] 陈贵良,姚林,张艳淑,2004.镉对鲫鱼主要脏器中锌、铜含量的影响[J].环境与职业医学,21(4):332-333.
[8] 冯志桐,赵爽,潘炯,等,2019.镉对转基因斑马鱼的急性毒性效应[J].天津理工大学学报,35(1):61-64.
[9] 龚仕玲,谢冬梅,李英文,等,2019.镉暴露诱导黄颡鱼鳃的组织学损伤、氧化应激和免疫反应[J].水生生物学报,43(2):340-347.
[10] 郭春晶,2013.鄱阳湖区水环境及经济鱼类重金属污染特征研究[D].南昌:南昌大学.
[11] 雷雯雯,2012.镉对长江化溪蟹心脏组织器官的毒性作用及机制研究[D].太原:山西大学.
[12] 李爽,王瑞俭,高凌,2018.镉对斑马鱼卵巢的毒性效应和子代响应[J].北华大学学报,19(4):532-535.
[13] 刘冰,周忠良,2007.镉对弹涂鱼肝细胞超微结构影响的初步观察[J].水产学报,31:29-33.
[14] 刘迪秋,葛锋,陈朝银,等,2010.重金属铜、镉对鲫肝脏基因表达的影响[J].中国水产科学,17:1243-1249.
[15] 刘燕,2014.水体中镉暴露对稀有鮈鲫氧化应激及组织学影响[D].重庆:西南大学.
[16] 罗永巨,2015.镉对吉富罗非鱼毒性效应及繁殖力影响的研究[D].南京:南京农业大学.
[17] 马广智,林浩然,张为民,1995.Cd2+对离体的鲤鱼脑垂体分泌促性腺激素的影响[J].动物学研究,16(3):255-261.
[18] 王俊能,赵学敏,胡国成,等,2019.广西龙江鱼类镉含量分布特征及生物积累特性分析[J].环境科学,40(1):488-495.
[19] 朱星樽,黎明,袁莉霞,等,2016.镉胁迫对黄颡鱼幼鱼抗氧化酶活性及免疫应答的影响[J].浙江海洋学院学报,35(6):478-482.
[20] Adam M A, Maftuch M, Kilawati Y, et al, 2019. The effect of cadmium exposure on the cytoskeleton and morphology of the gill chloride cells in juvenile mosquito fish (Gambu-sia affinis)[J]. The Egyptian Journal of Aquatic Research, 45(4):337-343.
[21] Ahmad M K, Islam S, Rahman S, et al, 2010. Heavy metals in water, sediment and some fishes of Buriganga river, Ban-gladesh[J]. International Journal of Environmental Re-search, 4(2):321-332.
[22] Annabi A, Messaoudi I, Kerkeni A, et al, 2011. Cadmium accu-mulation and histological lesion in mosquitofish (Gambusia affinis) tissues following acute and chronic exposure[J]. In-ternational Journal of Environmental Research, 5(3):745-756.
[23] Boudet L C, Paula P, Romero M B, 2013. Lethal and sublethal effects of cadmium in the white shrimp Palaemonetes argentinus:A comparison between populations from con-taminated and reference sites[J]. Ecotoxicology and Envi-ronmental Safety, 89:52-58.
[24] Camargo M M P, Martinez C B R, 2007. Histopathology of gills, kidney and liver of a Neotropical fish caged in an urban stream[J]. Neotropical Ichthyology, 5(3):327-336.
[25] Chmielowska-Bak J, Gzyl J, Ruci ñska-Sobkowiak R, et al, 2014. The new insights into cadmium sensing[J]. Fron-tiers in plant science, 5(2):76-83.
[26] Chouchene L, Banni M, Kerkeni A, 2011. Cadmium-induced ovarian pathophysiology is mediated by change in gene expression pattern of zinc transporters in zebrafish (Danio rerio)[J]. Chemico-Biological Interactions, 193(2):172-179.
[27] Cuypers A, Plusquin M, Remans T, et al, 2010. Cadmium stress:an oxidative challenge[J]. Biometals, 23:927-940.
[28] Das R C, 1988. Cadmium toxicity to gonads in a freshwater fish Labeo bata (Hamilton)[J]. Archiv Fur Hydrobiologie, 112:467-474.
[29] El-Sayed Y S, Ashry K E, EL-Gazzar A M, 2014. Physiologi-cal and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia,Oreochromis Niloticus L, Exposed to Sub-lethal Doses of Cadmium[J]. Alexandria Journal of Veteri-nary Sciences, 40:29-43.
[30] Fujiki K, Inamura H, Matsuoka M, 2016. Phosphorylation of FOX03a by PI3K/Akt pathway in HK-2 renal proximal tu-bular epithelial cells exposed to Archives of toxicology[J]. Toxicology, 87:2119-2127.
[31] Gao D, Xu Zhene, Zhang X Y, 2014. Molecular cloning, immu-nohistochemical localization, characterization and expres-sion analysis of caspase-9 from the purse red common carp (Cyprinus carpio) exposed to cadmium[J]. Comparative Biochemistry and Physiology Part C:Toxicology & Pharmacology, 160(1):15-22.
[32] Giari L, Manera M, Simoni E, et al, 2007. Cellular alterations in different organs of European sea bass Dicentrarchus labrax L. exposed to cadmium[J]. Chemosphere, 67(6):1171-1181.
[33] Guével R L, Petit F G, Goff P L, et al, 2000. Inhibition of rainbow trout (Oncorhynchus mykiss) estrogen receptor activity by Cadmium[J]. Biology of Reproduction, 63(1):259-266.
[34] Hallare A, Nagel K, Köhler H R, et al, 2006. Comparative em-bryotoxicity and proteotoxicity of three carrier solvents to zebrafish (Danio rerio) embryos[J]. Ecotoxicology and Environmental Safety, 63(3):378-388.
[35] Hua X Y, Huang X M, Tian J Q, et al, 2019. Migration and dis-tribution of cadmium in aquatic environment:The impor-tant role of natural biofilms[J]. Science of The Total Envi-ronment, 670:478-485.
[36] Jiang X Y, Guan X T, Yao L L, et al, 2016. Effects of single and joint subacute exposure of copper and cadmium on heat shock proteins in common carp (Cyprinus carpio)[J]. Biological Trace Element Research, 169(2):374-381.
[37] Jin Y X, Liu Z Z, Liu F, et al, 2015. Embryonic exposure to cad-mium (Ⅱ) and chromium (Ⅵ) induce behavioral altera-tions, oxidative stress and immunotoxicity in zebrafish (Da-nio rerio)[J]. Neurotoxicology and Teratology, 48:9-17.
[38] Kaneko J J, Ralston N V C, 2007. Selenium and mercury in pe-lagic fish in the central north pacific near Hawaii[J]. Bio-logical Trace Element Research, 119(3):242-254.
[39] Kim B M, Rhee J S, Jeong C B, et al, 2014. Heavy metals in-duce oxidative stress and trigger oxidative stress-mediat-ed heat shock protein (HSP) modulation in the intertidal copepod Tigriopus japonicas[J]. Comparative Biochemis-try and Physiology, Part C, 166(65):65-74.
[40] Liu D M, Yan B, Yang J, 2011. Mitochondrial pathway of apoptosis in the hepatopancreas of the freshwater crab Sinopotamon yangtsekiense exposed to cadmium[J]. Aquatic Toxicology, 105:394-402.
[41] Liu X J, Luo Z, Li C H, et al, 2011. Antioxidant responses, hepatic intermediary metabolism,histology and ultrastructure in Synechogobius hasta exposed to waterborne cadmium[J]. EcotoxicologyandEnvironmentalSafety, 74(5):1156-1163.
[42] Liu Z H, Li X J, Tai P D, et al, 2018. Toxicity of ammonia, cadmium,and nitrobenzene to four local fishes in the Li-ao River, China and the derivation of site-specific water quality criteria[J]. Ecotoxicology and Environmental Safe-ty, 147:656-663.
[43] López E, Arce C, Oset-Gasque M J, et al, 2006. Cadmium in-duces reactive oxygen species generation and lipid peroxi-dation in cortical neurons in culture[J]. Free Radical Biol-ogy and Medicine, 40(6):940-951.
[44] Lushchak V I, 2011. Environmentally induced oxidative stress in aquatic animals[J]. Aquatic Toxicology, 101:13-30.
[45] Monteiro D A, Rantin F T, Kalinin A L, 2010. Inorganic mer-cury exposure:toxicological effects,oxidative stress bio-markers and bioaccumulation in the tropical freshwater fish matrinxã,Brycon amazonicus (Spix and Agassiz, 1829)[J]. Ecotoxicology, 19(1):105-123.
[46] Najeeb U, Jilani G, Ali S, et al, 2010. Insights into cadmium in-duced physiological and ultra-structural disorders in Jun-cus effusus L. and its remediation through exogenous citric acid[J]. Journal of Hazardous Materials, 186(1):565-574.
[47] Nicola Franchi, Loriano Ballarin, 2013. Influence of cadmium on the morphology and functionality of haemocytes in the compound ascidian Botryllus schlosseri[J]. Comparative Biochemistry and Physiology, Part C, 158:29-35.
[48] Pan Luqing, Zhang Hongxia, 2006. Metallothionein,antioxi-dant enzymes and DNA strand breaks as biomarkers of Cd exposure in amarine crab, Charybdis japonica[J]. Compar-ative Biochemistry and Physiology, Part C, 144(1):67-75.
[49] Park S Y, Gopalakrishnan N P M, Choi J, 2012. Characterization and expression of superoxide dismutase genes in Chirono-mus riparius (Diptera, Chironomidae) larvae as a potential biomarker of ecotoxicity[J]. Comparative Biochemistry and Physiology, Part C, 156:187-194.
[50] Pereira J, Mercaldo-Allen R, Kuropat C, et al, 1993. Effect of cadmium accumulation on serum vitellogenin levels and hepatosomatic indices of winter flounder (Pleuronectes americanus)[J]. Archives of Environmental Contamina-tion and Toxicology, 24(4):427-431.
[51] Qu R J, Liu J Q, Wang L S, et al, 2016.The toxic effect and bio-accumulation in aquatic oligochaete Limnodrilus hoffmeis-teri after combined exposure to cadmium and perfluorooc-tane sulfonate at different pH values[J]. Chemosphere, 152:496-502.
[52] Qu R J, Wang X H, Feng M B, et al, 2013. The toxicity of cad-mium to three aquatic organisms (Photobacterium phos-phoreum,Daphnia magna and Carassius auratus) under different pH levels[J]. Ecotoxicology and Environmental Safety, 95:83-90.
[53] Rainbow P S,White S L,1989. Comparative strategies of heavy metal accumulation by crustaceans:zine, copper, and cadmium in decapods, an amphipod and a barnacle[J]. Hydrobiologia, 174(3):245-262.
[54] Rejomon G, Nair M, Joseph T, 2010. Trace metal dynamics in fishes from the southwest coast of India[J]. Environmen-tal Monitoring and Assessment, 167(1/4):243-255.Saad M A H, Hassan E M, 2002. Heavy metals in the Rosetta estuary of the Nile and the adjoining Mediterranean waters:evidence of removal of dissolved heavy metals from wa-ters as a result of possible binding to suspended matter[J]. Hydrobiologia, 469(1/3):131-147.
[55] Sib S G, Shib S S, Jin W J, 2016. Immunotoxicological effects of cadmium on Labeo rohita,with emphasis on the ex-pression of HSP genes[J]. Fish & Shellfish Immunology, 54:164-171.
[56] Stoica A, Katzenellenbogen B S, Martin M B, 2000. Activation of estrogen receptor- α by the heavy metal cadmium[J]. Molecular Endocrinology, 14(4):545-553.
[57] Thophon S, Kruatrachue M, Upatham E S, et al, 2003. Histo-pathological alterations of white seabass, Lates calcarifer, in acute and subchronic cadmium exposure[J]. Environ-mental Pollution, 121(3):307-320.
[58] Thophon S, Pokethitiyook P, Chalermw at K, et al, 2004. Ultra-structural alterations in the liver and kidney of white sea bass, Lates calcarifer,in acute and subchronic cadmium exposure[J]. Environmental Toxicology, 19(1):11-19.
[59] Tilton S C, Foran C M, Benson W H, 2003. Effects of cadmi-um on the reproductive axis of Japanese medaka (Oryzias latipes)[J]. Comparative Biochemistry and Physiology, Part C, 136:265-276.
[60] Vincent-Hubert F, Amélie C, Catherine G F, 2014. Metallothio-nein mRNA induction is correlated with the decrease of DNA strand breaks in cadmium exposed zebra mussels[J]. Mutation Research, 766:10-15.
[61] Wang Y, Fang J, Leonard S S, et al, 2004. Cadmium inhibits the electron transfer chain and induces reactive oxygen species[J]. Free Radical Biology and Medicine, 36(11):1434-1443.
[62] Wätjen W, Beyersmann D, 2004. Cadmium-induced apoptosis in C6 glioma cells:influence of oxidative stress[J]. Bio-metals, 17:65-78.
[63] Weber P, Behr E R, De Lellis Knorr C, et al, 2013. Metals in the water, sediment, and tissues of two fish species from different trophic levels in a subtropical Brazilian river[J]. Microchemical Journal, 106:61-66.

相关文章

[1] 陈晶, 聂青, 刘妍. 《WHO基本药物示范目录》与我国《国家基本药物目录》动态调整程序比较与借鉴.水产学报,2015(3): 289-293.doi:10.3866/PKU.WHXB201503022
  • 导出引用
  • 下载XML
  • 收藏文章
计量
  • 文章下载量()
  • 文章访问量()

目录

水环境中镉对鱼类的毒理效应研究进展