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ISSN 1000-0615

主管 中国科学技术协会

主办 中国水产学会

胍基乙酸对斑点叉尾鮰生长、肝脏抗氧化和肌肉能量代谢的影响

2024. 胍基乙酸对斑点叉尾鮰生长、肝脏抗氧化和肌肉能量代谢的影响. 水产学报, 48(3): 039614. doi: 10.11964/jfc.20211113150
引用本文: 2024. 胍基乙酸对斑点叉尾鮰生长、肝脏抗氧化和肌肉能量代谢的影响. 水产学报, 48(3): 039614. doi: 10.11964/jfc.20211113150
YU Hailuo, XIAO Tiaoyi, LUO Yiwen, WANG Hongquan, REN Wei, YE Lihai, ZHANG Yanling. 2024. Effect of dietary guanidinoacetic acid on growth, hepatic anti-oxidative capacity and muscle energy metabolism in channel catfish (Ictalurus punctatus). Journal of Fisheries of China, 48(3): 039614. doi: 10.11964/jfc.20211113150
Citation: YU Hailuo, XIAO Tiaoyi, LUO Yiwen, WANG Hongquan, REN Wei, YE Lihai, ZHANG Yanling. 2024. Effect of dietary guanidinoacetic acid on growth, hepatic anti-oxidative capacity and muscle energy metabolism in channel catfish (Ictalurus punctatus). Journal of Fisheries of China, 48(3): 039614. doi: 10.11964/jfc.20211113150

胍基乙酸对斑点叉尾鮰生长、肝脏抗氧化和肌肉能量代谢的影响

  • 基金项目:

    国家大宗淡水鱼产业技术体系(CARS-45-48)

详细信息
    作者简介:

    于海罗(照片),从事水生动物营养与生理研究,E-mail:yuhailuo.cool@163.com

    通讯作者: 肖调义,从事水产动物免疫与遗传研究,E-mail:tyxiao1128@163.com
  • 中图分类号: S 963.7

Effect of dietary guanidinoacetic acid on growth, hepatic anti-oxidative capacity and muscle energy metabolism in channel catfish (Ictalurus punctatus)

  • Fund Project: 国家大宗淡水鱼产业技术体系(CARS-45-48)
More Information
  • 为研究饲料中添加胍基乙酸(GAA)对斑点叉尾鮰生长、肝脏抗氧化以及肌肉能量代谢的影响。本实验共设计4个实验组,分别投喂含0(对照组)、300、600和900 mg/kg GAA(GAA0、GAA300、GAA600和GAA900)的等能等氮饲料,实验周期8周。结果显示,各添加GAA组末均重(FBW)和增重率(WGR)较对照组均有提高趋势,但差异不显著;添加GAA显著影响脏体比(VSI)和腹脂率(IPF),在GAA300组VSI和IPF最低;以IPF和VSI为评价指标,通过二次函数分析获得GAA最适量分别为275和150 mg/kg。添加GAA对全鱼水分、粗蛋白、粗脂肪和灰分均无显著影响,对肌肉中游离氨基酸和脂肪酸均无显著影响,但能显著提高肌肉中羟脯氨酸(HYP)含量,改善肌肉品质。添加GAA可提高肝脏抗氧化能力,其中GAA300组的总抗氧化能力(T-AOC)和超氧化物歧化酶(SOD)活性显著高于对照组。添加GAA可改善肌肉能量代谢,其中GAA300组的琥珀酸脱氢酶(SDH)和丙酮酸激酶(PK)活性显著高于对照组。研究表明,饲料中添加GAA对斑点叉尾鮰生长及饲料利用无显著促进作用,但添加150~300 mg/kg GAA能降低斑点叉尾鮰腹部脂肪含量和脏体比,并能提高肝脏抗氧化能力和肌肉能量代谢。
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  • 图 1  饲料中GAA水平对斑点叉尾鮰腹脂率的影响

    Figure 1.  Effect of different dietary GAA supplementation on IPF of I. punctatus

    图 2  饲料中GAA水平对斑点叉尾鮰脏体比的影响

    Figure 2.  Effect of different dietary GAA supplementations on VSI of I. punctatus

    表 1  基础饲料配方及常规成分(干物质)

    Table 1.  Formulation and proximate composition of the basal diet (air-dry basis) %

    项目 items含量 content项目 items含量 content
    国产鱼粉(62%) domestic fish meal 5.00 蛋氨酸 methionine 0.20
    猪肉粉(69%) pork meat powder 8.00 盐 NaCl 0.50
    豆粕(46%) soybean meal 34.00 矿物元素预混料1 mineral premix 0.50
    脱酚棉籽蛋白(60%) degossypolized cottonseed protein 5.00 维生素预混料2 vitamin premix 0.20
    菜粕(36%) rapeseed meal 10.00 氯化胆碱(75%) choline chloride 0.25
    面粉(15%) wheat flour 20.00 维生素C(35%) vitamin C 0.05
    米糠(13%) rice bran 9.38 抗氧化剂 antioxidants 0.02
    鱼油 fish oil 1.00 合计 total 100.00
    豆油 soybean oil 3.00 营养水平 nutrient levels
    磷酸二氢钙 calcium diphosphate 2.00 粗蛋白 crude protein 37.48
    酿酒酵母 brewer,s yeast meal 0.50 粗脂肪 crude lipid 6.67
    赖氨酸 lysine 0.40 粗灰分 crude ash 8.05
    注:1. 每千克维生素元素预混料含有维生素A乙酸酯480 mg、维生素D3 7.5 mg、维生素E 10 668 mg、维生素K3 800 mg、维生素B2 1 500 mg、维生素B6 1 600 mg、烟酸7 800 mg、泛酸钙4 700 mg、叶酸1 100 mg、水分12%;2. 每千克矿物元素预混料含锰2 000 mg、铁90 000 mg、锌5 000 mg、铜300 mg、镁47 000 mg、硒10 mg、水分12%。
    Notes: One kilogram of vitamin premix contains VA acetate 480 mg, VD3 7.5 mg, VE 10 668 mg, VK3 800 mg, VB2 1 500 mg, VB6 1 600 mg, niacin 7 800 mg, calcium pantothenate 4 700 mg, folic acid 1 100 mg, moisture 12%; one kilogram of mineral premix contained Mn 2 000 mg, Fe 90 000 mg, Zn 5 000 mg, Gu 300 mg, Mg 47 000 mg, Se 10 mg, moisture 12%.
    下载: 导出CSV

    表 2  饲料中GAA水平对斑点叉尾鮰生长和饲料利用的影响

    Table 2.  Effect of different dietary GAA supplementation on growth performance and feed utilization of I. punctatus

    项目 itemsGAA0GAA300GAA600GAA900P值 P-value
    初始体重/g IBW 36.67±0.00 37.09±0.27 36.88±0.21 36.91±0.51 0.815
    终末体重/g FBW 145.96±0.89 147.37±0.99 147.22±1.13 146.88±0.51 0.780
    增重率/% WGR 298.06±2.43 299.24±3.74 299.24±3.03 298.55±2.32 0.989
    特定生长率/% SGR 2.47±0.01 2.47±0.02 2.47±0.01 2.47±0.01 0.983
    饲料系数/% FCR 1.18±0.01 1.18±0.01 1.18±0.02 1.19±0.01 0.964
    肝体比/% HSI 1.13±0.04 1.13±0.04 1.17±0.04 1.18±0.01 0.633
    脏体比/% VSI 7.74±0.16ab 7.51±0.18a 8.06±0.22ab 8.43±0.06b 0.014
    腹脂率/% IPF 3.94±0.24ab 3.72±0.15a 4.06±0.05ab 4.58±0.25b 0.043
    肥满度/(g/cm3) CF 1.54±0.03 1.59±0.05 1.54±0.03 1.53±0.04 0.748
    成活率/% SR 100.00±0.00 99.45±0.56 99.45±0.56 98.89±1.11 0.724
    注:同一行数值上标不同字母表示差异显著(P < 0.05);下同。
    Notes: Values in the same row with different superscripts are significant different (P < 0.05); the same below.
    下载: 导出CSV

    表 3  饲料中GAA水平对斑点叉尾鮰体成分的影响

    Table 3.  Effect of different dietary GAA supplementation on body nutritional composition of I. punctatus

    项目 itemsGAA0GAA300GAA600GAA900P值 P-value
    水分/% moisture 71.87±0.53 72.07±0.05 71.87±0.40 72.00±0.48 0.980
    粗蛋白/% crude protein 14.07±0.42 14.28±0.31 14.07±0.07 14.06±0.18 0.929
    粗脂肪/% crude lipid 9.67±0.26 9.13±0.34 9.77±0.32 9.11±0.28 0.326
    粗灰分/% crude ash 3.11±0.07 3.26±0.09 3.19±0.04 3.17±0.01 0.432
    下载: 导出CSV

    表 4  饲料中GAA水平对斑点叉尾鮰肌肉糖原和羟脯氨酸含量的影响

    Table 4.  Effect of different dietary GAA supplementation on glycogen and hydroxyproline in muscle of I. punctatus

    项目 itemsGAA0GAA300GAA600GAA900P值 P-value
    肌糖原/(mg/g) muscle glycogen 0.38±0.02 0.40±0.02 0.42±0.02 0.43±0.02 0.298
    羟脯氨酸/(μg/g) HYP 8.40±1.01a 14.36±0.81b 20.83±0.79c 25.94±1.51c 0.000
    下载: 导出CSV

    表 5  饲料中GAA水平对斑点叉尾鮰肌肉氨基酸组成的影响

    Table 5.  Effect of different dietary GAA supplementation on free amino acid composition                   in muscle of I. punctatus (dry matter)                  μg/g

    项目 itemsGAA0GAA300GAA600GAA900P值 P-value
    苏氨酸 Thr 184.33±10.01 201.73±14.34 189.11±10.49 172.62±4.86 0.297
    缬氨酸 Val 60.01±2.75 57.02±2.30 57.07±3.32 58.08±5.58 0.179
    蛋氨酸 Met 2.48±0.35 1.92±0.27 1.60±0.44 1.80±0.23 0.290
    异亮氨酸 Ile 18.78±3.88 21.34±2.53 19.71±2.65 28.58±2.03 0.104
    亮氨酸 Leu 60.33±4.00 64.65±1.58 68.60±3.74 61.05±3.01 0.276
    苯丙氨酸 Phe 172.36±7.54 152.62±15.41 144.59±6.07 141.17±14.99 0.271
    赖氨酸 Lys 159.91±12.28 147.81±14.22 184.69±15.32 158.96±14.94 0.337
    组氨酸 His 51.93±3.80 53.97±2.08 59.61±5.26 54.96±3.55 0.605
    精氨酸 Arg 77.10±3.09 70.61±9.45 67.36±10.42 67.29±6.24 0.770
    脯氨酸 Pro 71.20±4.78 68.97±4.98 69.78±2.28 78.78±7.42 0.622
    天冬氨酸 Asp 14.86±1.37 16.22±0.90 16.47±2.88 17.14±2.32 0.821
    丝氨酸 Ser 61.89±5.30 55.43±2.77 55.80±5.43 64.22±6.50 0.569
    谷氨酸 Glu 157.21±7.20 157.73±4.77 154.04±7.96 147.49±17.13 0.865
    甘氨酸 Gly 222.14±19.53 207.06±15.73 186.84±15.58 187.31±12.73 0.363
    丙氨酸 Ala 302.87±3.50 323.85±13.27 325.52±10.07 315.02±15.24 0.559
    半胱氨酸 Cys 18.43±1.73 18.64±1.01 16.88±0.29 18.61±2.86 0.868
    酪氨酸 Tyr 66.60±3.17 76.33±1.67 70.09±1.63 73.39±4.01 0.115
    非必需氨基酸 NEAA 1013.18±14.53 1046.97±48.55 1009.20±38.29 1002.79±58.91 0.896
    必需氨基酸 EAA 1711.26±59.96 1697.04±77.19 1701.59±23.15 1648.52±87.57 0.923
    下载: 导出CSV

    表 6  饲料中GAA水平对斑点叉尾鮰肌肉脂肪酸含量的影响

    Table 6.  Effect of different dietary GAA supplementation on the fatty acid (FA) of total FA in muscle of I. punctatus %

    项目 itemsGAA0GAA300GAA600GAA900P值 P-value
    C14:0 1.06±0.02 1.13±0.04 1.15±0.06 1.07±0.02 0.299
    C15:0 0.17±0.00 0.17±0.00 0.17±0.00 0.17±0.00 0.863
    C16:0 19.61±0.12 19.20±0.25 19.82±0.26 19.71±0.31 0.337
    C17:0 0.25±0.01 0.25±0.01 0.24±0.01 0.25±0.01 0.674
    C18:0 8.73±0.10 8.50±0.33 7.97±0.32 8.56±0.14 0.191
    C20:0 0.25±0.01 0.27±0.00 0.25±0.01 0.26±0.00 0.357
    C22:0 0.07±0.00 0.08±0.00 0.08±0.01 0.08±0.00 0.427
    C24:0 1.45±0.08 1.26±0.08 1.34±0.12 1.46±0.09 0.409
    C16:1 1.41±0.02 1.48±0.07 1.56±0.09 1.47±0.03 0.414
    C18:1n9t 0.22±0.00 0.22±0.01 0.21±0.01 0.20±0.01 0.206
    C18:1n9c 35.40±0.99 36.29±0.52 36.23±0.77 35.19±0.99 0.718
    C20:1 1.25±0.03 1.32±0.03 1.24±0.04 1.21±0.01 0.063
    C18:2n6c 18.06±0.23 19.29±0.28 18.30±0.54 18.24±0.13 0.088
    C18:3n6 0.22±0.01 0.25±0.01 0.25±0.02 0.23±0.01 0.193
    C18:3n3 1.50±0.04 1.66±0.03 1.54±0.08 1.53±0.04 0.154
    C20:2 1.31±0.05 1.18±0.03 1.18±0.04 1.26±0.00 0.115
    C20:3n3 0.12±0.01 0.11±0.01 0.11±0.01 0.12±0.00 0.465
    C20:3n6 1.55±0.10 1.39±0.06 1.34±0.05 1.59±0.11 0.159
    C20:4n6 1.68±0.12 1.25±0.12 1.33±0.13 1.44±0.10 0.079
    C20:5n3 (EPA) 0.02±0.01 0.02±0.01 0.02±0.01 0.02±0.01 0.979
    C22:6n3 (DHA) 5.74±0.49 4.52±0.32 4.50±0.26 5.22±0.28 0.072
    n3 PUFA 7.57±0.40 6.32±0.30 6.89±0.65 7.26±0.40 0.546
    n6 PUFA 21.51±0.24 22.17±0.27 21.55±0.28 21.80±0.30 0.301
    n3/n6 0.35±0.02 0.29±0.01 0.31±0.03 0.33±0.02 0.324
    饱和脂肪酸 SFA 31.29±0.44 30.88±0.19 31.06±0.40 31.06±0.44 0.595
    单不饱和脂肪酸 MUFA 38.30±1.03 39.38±0.58 39.30±0.89 38.07±1.07 0.659
    多不饱和脂肪酸 PUFA 30.96±0.32 29.74±0.44 29.63±0.54 30.33±0.68 0.332
    下载: 导出CSV

    表 7  饲料中GAA水平对斑点叉尾鮰肝脏抗氧化指标的影响

    Table 7.  Effect of different dietary GAA supplementation on hepatic antioxidant indices of I. punctatus

    项目 itemsGAA0GAA300GAA600GAA900P值 P-value
    总抗氧化力/(U/mg prot) T-AOC 0.12±0.01a 0.17±0.01b 0.13±0.00a 0.12±0.01a 0.003
    谷胱甘肽过氧化物酶/(U/mg prot) GSH-Px 20.91±3.89 26.22±6.70 23.50±1.36 24.03±0.49 0.820
    丙二醛/(nmol/mg prot) MDA 0.41±0.02a 0.62±0.10a 1.10±0.12b 1.12±0.12b 0.001
    超氧化物歧化酶/(U/mg prot) SOD 966.18±6.81a 1191.42±26.06b 1236.50±65.17b 1133.99±40.61ab 0.007
    过氧化氢酶/(U/mg prot) CAT 0.43±0.02 0.43±0.03 0.45±0.05 0.45±0.04 0.944
    下载: 导出CSV

    表 8  饲料中GAA水平对斑点叉尾鮰肌肉能量代谢酶的影响

    Table 8.  Effect of different dietary GAA supplementation on the activities of muscle energy enzymes of I. punctatus

    项目 itemsGAA0GAA300GAA600GAA900P值 P-value
    肌酸激酶/(U/mg prot) CK 5.74±0.23 5.84±0.25 6.13±0.19 6.03±0.23 0.668
    琥珀酸脱氢酶/(U/mg prot) SDH 11.11±0.11a 14.02±0.66b 12.88±0.70ab 13.31±0.54ab 0.028
    丙酮酸激酶/(U/g prot) PK 82.59±1.44a 96.00±2.45b 103.98±2.73b 84.85±2.40a 0.001
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出版历程
收稿日期:  2021-11-10
修回日期:  2022-03-16
刊出日期:  2024-03-01

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